Author/Authors :
Mallo، نويسنده , , Mar and Espinet، نويسنده , , Blanca and Salido، نويسنده , , Marta and Ferrer، نويسنده , , Ana M. Pedro، نويسنده , , Carmen and Besses، نويسنده , , Carles and Pérez-Vila، نويسنده , , Encarna and Serrano، نويسنده , , Sergi and Florensa، نويسنده , , Lourdes and Solé، نويسنده , , Francesc، نويسنده ,
Abstract :
Granulocytic sarcomas (GS) are tumor masses of immature myeloid cells presenting at an extramedullary site, mainly the skin, bone, and lymph node. They are often associated with acute myeloid leukemia (AML) with monoblastic or myelomonocytic differentiation, including either AML M2 with t(8;21)(q22;q22) or AML M4Eo with inv(16)(p13q22). We present a case diagnosed with GS associated with AML M4 that presented a normal karyotype with conventional cytogenetic analysis. Although the myeloblasts did not show the inv(16)(p13q22) (CBFB/MYH11), a gain of multiple copies of the CBFB gene was detected with fluorescence in situ hybridization analysis. To our knowledge, no cases with this rare genetic anomaly have been previously described.
