Author/Authors :
Soler، نويسنده , , Gwendoline and Radford، نويسنده , , Isabelle and Meyer، نويسنده , , Claus and Marschalek، نويسنده , , Rolf and Brouzes، نويسنده , , Chantal and Ghez، نويسنده , , David and Romana، نويسنده , , Serge and Berger، نويسنده , , Roland، نويسنده ,
Abstract :
A new chromosomal insertion involving the MLL gene was detected by fluorescence in situ hybridization in a patient with acute myeloblastic leukemia (AML) and a t(9;11)(p21;q13). Genomic polymerase chain reaction confirmed the MLL-MLLT3 gene fusion. A review of the literature on MLL insertions shows that the opposite orientation of the genes involved in the fusion plays a role in the genesis of the rearrangement in most of the cases reported.
