Title of article
A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia
Author/Authors
Cirmena، نويسنده , , Gabriella and Aliano، نويسنده , , Stefania and Fugazza، نويسنده , , Giuseppina and Bruzzone، نويسنده , , Roberto and Garuti، نويسنده , , Anna and Bocciardi، نويسنده , , Renata and Bacigalupo، نويسنده , , Andrea and Ravazzolo، نويسنده , , Roberto and Ballestrero، نويسنده , , Alberto and Sessarego، نويسنده , , Mario، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
105
To page
108
Abstract
We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality. The BCR-JAK2 fusion gene has the same breakpoint in BCR as is found in the BCR/ABL p210. The chimeric gene is the result of a reciprocal translocation between chromosomes 9 and 22, which implies a double break on chromosome 9; this has allowed generating an in-frame fusion transcript. Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different.
Journal title
Cancer Genetics and Cytogenetics
Serial Year
2008
Journal title
Cancer Genetics and Cytogenetics
Record number
1829059
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