Author/Authors :
Cirmena، نويسنده , , Gabriella and Aliano، نويسنده , , Stefania and Fugazza، نويسنده , , Giuseppina and Bruzzone، نويسنده , , Roberto and Garuti، نويسنده , , Anna and Bocciardi، نويسنده , , Renata and Bacigalupo، نويسنده , , Andrea and Ravazzolo، نويسنده , , Roberto and Ballestrero، نويسنده , , Alberto and Sessarego، نويسنده , , Mario، نويسنده ,
Abstract :
We report the occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality. The BCR-JAK2 fusion gene has the same breakpoint in BCR as is found in the BCR/ABL p210. The chimeric gene is the result of a reciprocal translocation between chromosomes 9 and 22, which implies a double break on chromosome 9; this has allowed generating an in-frame fusion transcript. Previously, BCR-JAK2 rearrangement was observed in a single case with atypical chronic myelogenous leukemia (CML), but in that case the breakpoint in the BCR was different.
