Author/Authors :
Villa، نويسنده , , Olaya and Salido، نويسنده , , Marta and Pérez-Vila، نويسنده , , Marيa Encarnaciَn and Ferrer، نويسنده , , Ana and Arenillas، نويسنده , , Leonor and Pedro، نويسنده , , Carmen and Espinet، نويسنده , , Blanca and Corzo، نويسنده , , Cristina and Serrano، نويسنده , , Sergi and Woessner، نويسنده , , Soledad and Florensa، نويسنده , , Lourdes and Solé، نويسنده , , Francesc، نويسنده ,
Abstract :
We report three cases of acute myeloid leukemia without maturation [AML-M1 subtype according to the French-American-British classification (FAB)] with the presence of MYC oncogene amplification in form of double minutes (dmin) or homogeneously staining region (hsr). Blasts cells showed a particular morphology with extrusion of chromatin material. We observed by FISH the phenomenon of MYC aggregation in interphase cells and the formation of micronuclei excluded from the nucleus. The appearance of chromatin extrusion in cytological analysis should draw attention of the presence of dmin aggregation and possible MYC amplification.
