Author/Authors :
Park، نويسنده , , Tae-Sung and Lee، نويسنده , , Seung-Tae and Kim، نويسنده , , Jin Seok and Song، نويسنده , , Jaewoo and Lee، نويسنده , , Kyung-A. and Kim، نويسنده , , Sue Jung and Seok، نويسنده , , Yoon-Mi and Lee، نويسنده , , Hyeon-Ji and Han، نويسنده , , Jeong-Hyun and Kim، نويسنده , , Jong-Kee and Lee، نويسنده , , Eun Yup and Choi، نويسنده , , Jong Rak، نويسنده ,
Abstract :
A 32-year-old pregnant woman in the 13th gestational week was brought to Severance Hospital with gum bleeding and easy bruising. Initial laboratory results revealed anemia and thrombocytopenia. In a peripheral blood smear, 81% of leukocytes were large, abnormal promyelocytes. Bone marrow aspiration showed a hypercellular marrow with packed leukemic promyelocytes, and chromosome study revealed a karyotype of 46,XX,t(15;17)(q22;q21)[10]/46,XX[10]. In addition, variant fusion transcripts of PML/RARA were detected in the marrow specimen. The patient was diagnosed with acute promyelocytic leukemia (APL) and was treated with all-trans retinoic acid (ATRA) and idarubicin. One month from the patientʹs initial diagnosis a follow-up bone marrow examination was performed, revealing complete remission (CR). We know of no previous reports of APL during pregnancy associated with variant PML/RARA fusion transcripts. Here, we describe a novel case of APL in a pregnant woman with a t(15;17) translocation and variant fusion transcripts.
