MYC gene amplification in double minute chromosomes in an aggressive large B-cell lymphoma with leukemic presentation: a case report

Double-minute chromosomes (dmin) are small chromatin particles that lack a centromere. They represent extrachromsomal form of gene amplification. Dmin are very rarely encountered in lymphoid neoplasms. We describe a case of a leukemic presentation of large B-cell lymphoma with dmin. Fluoresence in situ hybridization analysis identified these dmin as comprising MYC genes.