Author/Authors :
Kim، نويسنده , , Juwon and Park، نويسنده , , Tae Sung and Song، نويسنده , , Jaewoo and Lee، نويسنده , , Kyung-A. and Hong، نويسنده , , Duk Jin and Min، نويسنده , , Yoo Hong and Cheong، نويسنده , , June-Won and Choi، نويسنده , , Jong Rak، نويسنده ,
Abstract :
Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS–ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.
