Author/Authors :
??rov?، نويسنده , , Iveta and B?ezinov?، نويسنده , , Jana and Zemanov?، نويسنده , , Zuzana and Lizcov?، نويسنده , , Libu?e and Berkov?، نويسنده , , Adéla and Iz?kov?، نويسنده , , Silvia and Malinov?، نويسنده , , Eva and Fuchs، نويسنده , , Ota and Koste?ka، نويسنده , , Arno?t and Provazn?kov?، نويسنده , , Dana and Filkukov?، نويسنده , , Jitka and Maaloufov?، نويسنده , , Jacqueline and Star?، نويسنده , , Jan a، نويسنده ,
Abstract :
Unusual MLL gene rearrangements were found in bone marrow cells of four patients with acute myeloid leukemia. A combination of conventional and molecular cytogenetic methods were used to describe translocations t(9;12;11)(p22;p13;q23), t(11;19)(q23;p13.3), and t(10;11)(p12;23) and inverted insertion ins(10;11)(p12;q23.3q23.1). Partial nontandem duplication of the MLL gene was identified by reverse transcriptase–polymerase chain reaction in all cases. The duplication, which included MLL exons 2 through 8–9, was interrupted by a cryptic insertion of one or two exons from the respective MLL partner gene: MLLT10, MLLT3, or MLLT1.
