Author/Authors :
Yang، نويسنده , , Dae Sik and Sung، نويسنده , , Hwa Jung and Woo، نويسنده , , Ok Hee and Park، نويسنده , , Kyong Hwa and Woo، نويسنده , , Sang Uk and Kim، نويسنده , , Ae-Ree and Lee، نويسنده , , Eun Sook and Lee، نويسنده , , Jae-Bok and Kim، نويسنده , , Yeul Hong and Kim، نويسنده , , Jun Suk and Seo، نويسنده , , Jae Hong، نويسنده ,
Abstract :
Published studies on the association between the progesterone receptor gene +331 G/A polymorphism and breast cancer risk are inconclusive, and meta-analysis is required to verify the association. Six studies, including a total of 6,849 cases and 6,589 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the AG + AA variant genotype was not associated with a significantly elevated breast cancer risk [odds ratio (OR) = 1.11; 95% confidence interval (95%CI) = 0.99–1.24; P = 0.071]. However, subgroup analysis revealed that the AG + AA variant genotype was associated with an increased risk of breast cancer in American (OR = 1.32; 95%CI = 1.10–1.58; P = 0.003), but not in European or Australian. We could carefully suggest that the progesterone receptor promoter +331 G/A variant polymorphism might increase breast cancer risk, and this effect appeared to be more prominent in Americans than in Europeans and Australians.
