Author/Authors :
Nowak، نويسنده , , Norma J. and Sait، نويسنده , , Sheila N.J. and Zeidan، نويسنده , , Amer and Deeb، نويسنده , , George and Gaile، نويسنده , , Dan and Liu، نويسنده , , Song and Ford، نويسنده , , LaurieAnn and Wallace، نويسنده , , Paul K. and Wang، نويسنده , , Eunice S. and Wetzler، نويسنده , , Meir، نويسنده ,
Abstract :
The prognosis of adult normal karyotype (NK) precursor B-cell acute lymphoblastic leukemia (B-ALL) has not improved over the last decade, mainly because separation into distinct molecular subsets has been lacking and no targeted treatments are available. We screened the genome of blasts from 10 adult NK B-ALL patients for novel genomic alterations by array comparative genomic hybridization and verified our results with fluorescent in situ hybridization and gene expression profile with the same probes. The results demonstrate cryptic deletions of 9q34 involving SET, PKN3, NUP188, ABL1, and NUP214 in three of the samples. The smallest deletion resulted in the likely juxtaposition of the SET and NUP214 genes. This aberration has not been described before in adult NK B-ALL. Larger number of samples is warranted to determine the prognostic significance of this cryptic deletion.
