Activity revealed in MRI of multiple sclerosis without contrast agent A preliminary report

Disease activity in multiple sclerosis is usually accompanied by blood–brain barrier disruption, which can be assessed with contrast-enhanced magnetic resonance imaging (MRI). This paper describes a technique that gives information about disease activity using magnetization transfer MRI. Image combination methods using follow-up scans, like the one presented here, have the potential to show MS lesions that correlate with enhancement.