Author/Authors :
Charafeddine، نويسنده , , Khalil M. and Mahfouz، نويسنده , , Rami A. and Zaatari، نويسنده , , Ghazi S. and Ibrahim، نويسنده , , Georges Y. and Muwakkit، نويسنده , , Samar A. and Najm، نويسنده , , Nada D. and Farra، نويسنده , , Chantal G. Lamontagne، نويسنده ,
Abstract :
Translocations involving chromosomes 1 and 15 are uncommon in hematologic malignancies. So far, only 42 cases have been reported with t(1;15) as a reciprocal or complex chromosomal abnormalities. We herein report the first case in the literature, to our knowledge, of a 44-year-old female with essential thrombocythemia and severe myelofibrosis who developed acute myeloid leukemia (AML-M4) with der(1;15)(q10;q10) after 13 years of treatment. In addition, we reviewed the literature for all up-to-date published cases with t(1;15).
