Author/Authors :
Lowery، نويسنده , , Thomas J. and Rubin، نويسنده , , Seth M. and Ruiz، نويسنده , , E.Janette and Spence، نويسنده , , Megan M. and Winssinger، نويسنده , , Nicolas and Schultz، نويسنده , , Peter G. and Pines، نويسنده , , Alexander and Wemmer، نويسنده , , David E.، نويسنده ,
Abstract :
The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized 129Xe have motivated the application of 129Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized 129Xe in biomolecular assays that detect ligand-binding events and distinguish protein conformations. The successful application of unfunctionalized and functionalized 129Xe NMR to in vitro biomolecular assays suggests the potential future use of a functionalized xenon biosensor for in vivo imaging.
Keywords :
Ligand-protein interactions , protein conformation assay , xenon binding , Biosensor
