Author/Authors :
Giove، نويسنده , , Federico and Garreffa، نويسنده , , Girolamo and Peca، نويسنده , , Stefano and Carnي، نويسنده , , Marco and Macrى، نويسنده , , Maria Antonietta and Di Bonaventura، نويسنده , , Carlo and Vaudano، نويسنده , , Anna Elisabetta and Giallonardo، نويسنده , , Anna Teresa and Prencipe، نويسنده , , Massimiliano and Bozzao، نويسنده , , Luigi and Pantano، نويسنده , , Patrizia and Colonnese، نويسنده , , Claudio and Maraviglia، نويسنده , , Bruno، نويسنده ,
Abstract :
The purpose of this study was to investigate short-time metabolic variations related to continuous epileptic activity elicited by fixation-off sensitivity (FOS). Time-resolved magnetic resonance spectroscopy was performed on a patient on whom previous clinical findings clearly indicated presence of FOS. The epileptic focus was localized with a simultaneous electroencephalographic and functional magnetic resonance imaging study. The results showed a linear increase of the sum of glutamate and glutamine with time of paroxysmal activity in epileptic focus and much greater concentration of choline-containing compounds in focus than in the contralateral side.
Keywords :
Functional magnetic resonance spectroscopy , Time resolved , Epilepsy , glutamate , Fixation-off sensitivity
