Title of article :
MRI quantification of diffusion and perfusion in bone marrow by intravoxel incoherent motion (IVIM) and non-negative least square (NNLS) analysis
Author/Authors :
Marchand، نويسنده , , A.J. and Hitti، نويسنده , , E. and Monge، نويسنده , , F. and Saint-Jalmes، نويسنده , , H. and Guillin، نويسنده , , R. and Duvauferrier، نويسنده , , R. and Gambarota، نويسنده , , G.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Pages :
6
From page :
1091
To page :
1096
Abstract :
AbstractObject ess the feasibility of measuring diffusion and perfusion fraction in vertebral bone marrow using the intravoxel incoherent motion (IVIM) approach and to compare two fitting methods, i.e., the non-negative least squares (NNLS) algorithm and the more commonly used Levenberg–Marquardt (LM) non-linear least squares algorithm, for the analysis of IVIM data. als and Methods periments were performed on fifteen healthy volunteers, with a diffusion-weighted echo-planar imaging (EPI) sequence at five different b-values (0, 50, 100, 200, 600 s/mm2), in combination with an STIR module to suppress the lipid signal. Diffusion signal decays in the first lumbar vertebra (L1) were fitted to a bi-exponential function using the LM algorithm and further analyzed with the NNLS algorithm to calculate the values of the apparent diffusion coefficient (ADC), pseudo-diffusion coefficient (D*) and perfusion fraction. s LS analysis revealed two diffusion components only in seven out of fifteen volunteers, with ADC = 0.60 ± 0.09 (10− 3 mm2/s), D* = 28 ± 9 (10− 3 mm2/s) and perfusion fraction = 14% ± 6%. The values obtained by the LM bi-exponential fit were: ADC = 0.45 ± 0.27 (10− 3 mm2/s), D* = 63 ± 145 (10− 3 mm2/s) and perfusion fraction = 27% ± 17%. Furthermore, the LM algorithm yielded values of perfusion fraction in cases where the decay was not bi-exponential, as assessed by NNLS analysis. sion IM approach allows for measuring diffusion and perfusion fraction in vertebral bone marrow; its reliability can be improved by using the NNLS, which identifies the diffusion decays that display a bi-exponential behavior.
Keywords :
Intravoxel incoherent motion , IVIM , diffusion , Bone marrow , Perfusion , NNLS
Journal title :
Magnetic Resonance Imaging
Serial Year :
2014
Journal title :
Magnetic Resonance Imaging
Record number :
1834518
Link To Document :
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