Biliary tract cancers: Molecular profiling as a tool for treatment decisions. A literature review

Summary y tract cancer is a quite rare disease; despite recent significant advances in imaging modalities, most of the patients have advanced disease at presentation thus making radical surgery not feasible. ifferent chemotherapeutic regimens have been investigated in small uncontrolled studies, with generally disappointing results. ensively reviewed the literature on this topic trying to give an explanation to chemoresistance in this setting of patients and considering the molecular profiling as a tool for treatment decision. eview is divided in two parts, in the first one we illustrated chemotherapy results and possible mechanisms of resistance. second part we analysed the new molecular targets developing an hypothesis about the future therapeutics perspectives.