Author/Authors :
Alonso، نويسنده , , Vivian and Neves، نويسنده , , Adriana F. and Marangoni، نويسنده , , Karina and Faria، نويسنده , , Paula C.B. and Freschi، نويسنده , , Ana Paula P. and Capaneli، نويسنده , , Andréia C. and Meola، نويسنده , , Juliana and Goulart، نويسنده , , Luiz R.، نويسنده ,
Abstract :
Background: Prostate cancer consists of multifactorial and multifocal events, generating differential gene expression in tumor cells. Methods: The molecular profile of 14 gene expression was analyzed through cDNA array in blood samples of patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Results: Messenger RNA from patientʹs blood showed significant differences between PCa and BPH groups only for the NOS3 gene, with an occurrence chance for PCa 5.8-fold higher than BPH disease. Conclusion: The NOS3 gene expression in the patientʹs blood may be used as a putative biomarker for prostate cancer.
Keywords :
prostate cancer , Peripheral Blood , Slot-blot array , Gene expression
