Title of article :
Targeted therapies and complete responses in first line treatment of metastatic renal cell carcinoma. A meta-analysis of published trials
Author/Authors :
Iacovelli، نويسنده , , Roberto and Alesini، نويسنده , , Daniele and Palazzo، نويسنده , , Antonella and Trenta، نويسنده , , Patrizia and Santoni، نويسنده , , Matteo and De Marchis، نويسنده , , Laura and Cascinu، نويسنده , , Stefano and Naso، نويسنده , , Giuseppe and Cortesi، نويسنده , , Enrico، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Abstract :
Antiangiogenic agents (AAs) have reported grater efficacy compared to interferon. Despite these advances, radiological complete response to therapy is rare. We meta-analyzed the incidence of complete response in patients treated with AAs and in controls in main randomized clinical trials for first-line therapy in metastatic renal cell carcinoma.
was reviewed for phase II–III randomized clinical trials with AAs vs. non-AAs in patients with good or intermediate prognosis. We calculated the relative risk of events in patients assigned to AAs compared to control.
CTs were found; four were phase III and one was phase II. A total of 2747 patients was valuable for final analysis and randomized to receive AAs or control. Patients in the control-group had interferon (85%) or placebo (15%); patients in the AAs-group received bevacizumab (48%), sunitinib (26%), pazopanib (20%) or sorafenib (6%).
cidence of complete response in patients treated with AAs was 2.0% (95% CI, 1.2–2.8) compared to 1.4% (95% CI, 0.7–2.1) in the control arm. Comparing the different type of AAs, the incidence of complete response was 2.5% (95% CI, 1.2–3.8) in the bevacizumab group and 1.6% (95% CI, 0.1–2.5) in the TKIs group. The relative risk to have a complete response was 1.52 (95% CI, 0.85–2.73; p = 0.16) in patients treated with AAs compared to controls; this was found higher in patients treated with TKIs compared to bevacizumab.
mplete response is a rare event in metastatic kidney tumor, even if AAs reported greater efficacy in terms of progression-free survival and of overall response rate, they did not increase the curative rate of metastatic disease. Probably, some biologic factors other than angiogenesis may influence the complete response in this disease.
Keywords :
sorafenib , Sunitinib , Complete response , cytokines , Pazopanib , Interferon , Bevacizumab , Metastatic renal cells cancer , Antiangiogenic agents
Journal title :
Cancer Treatment Reviews
Journal title :
Cancer Treatment Reviews