Title of article :
Epigenetic targeting in pancreatic cancer
Author/Authors :
van Kampen، نويسنده , , Jasmijn G.M. and Marijnissen-van Zanten، نويسنده , , Monica A.J. and Simmer، نويسنده , , Femke and van der Graaf، نويسنده , , Winette T.A. and Ligtenberg، نويسنده , , Marjolijn J.L. and Nagtegaal، نويسنده , , Iris D.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Abstract :
The prognosis of pancreatic cancer patients is very poor, with a 5-year survival of less than 6%. Therefore, there is an urgent need for new therapeutic options in pancreatic cancer. In the past years it became evident that deregulation of epigenetic mechanisms plays an important role in pancreatic carcinogenesis. This review focuses on the exploitation of drugs that alter histone modifications, DNA methylation and microRNA expression as options for the treatment of pancreatic cancer.
Keywords :
Epigenetics , pancreatic cancer , Histone methyltransferase inhibitor , DNA methyltransferase inhibitor , Histone deacetylase inhibitor , MicroRNA , Therapy
Journal title :
Cancer Treatment Reviews
Journal title :
Cancer Treatment Reviews
