Place de la radiothérapie dans le traitement des formes ganglionnaires des lymphomes non hodgkiniens de lʹadulte

Summary le of radiotherapy in the treatment of nodal non-Hodgkinʹs lymphoma has been modified by the introduction of efficient chemotherapy and the development of different pathological classifications. ediate grade or high grade lymphoma commended treatment of early-stage aggressive lymphomas is primarily a combination chemotherapy. The interest of adjuvant radiotherapy remains unclear and has to be established through large prospective trials. If radiation therapy has to be delivered, the historical results of exclusive radiation therapy showed that involved-fields and a dose of 35–40 Gy (daily fraction of 1.8 Gy, 5 days a week) are the optimal schedule. The interest of radiotherapy in the treatment of advanced-stage aggressive lymphoma is yet to be proven. Further studies had to stratify localized stages according to the factors of the International Prognostic Index. ade lymphoma rly-stage low-grade lymphoma, radiotherapy remains the standard treatment. However, the appropriate technique to use is controversial. Involved-field irradiation at a dose of 35 Gy seems to be the optimal schedule, providing a 10-year disease-free survival rate of 50% and no major toxicity. There is no standard indication of radiotherapy in the treatment advanced-stage low-grade lymphoma. nd new entity ew” nodal lymphomaʹs types, the indication of radiotherapy cannot be established (mantle-zone lymphoma, marginal zone B-cell lymphoma) or must take into account the natural history (Burkittʹs lymphoma, peripheral T-cell lymphoma) and the sensibility to others therapeutic methods.