Title of article :
Access to lincomycin N-oxide isomers controlled by reaction conditions
Author/Authors :
Posp???il، نويسنده , , Stanislav and Sedmera، نويسنده , , Petr and Halada، نويسنده , , Petr and Havlicek، نويسنده , , Libor and Sp???ek، نويسنده , , Jaroslav، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
Oxidation of lincomycin with H2O2 in alkaline media leads to N-oxides, besides the conversion of thiomethyl group into sulfoxides and sulfones. NH4OH favors formation of the S-isomer; both R- and S-isomers of the N-oxide are formed in the presence of NaOH. Addition of acetonitrile markedly accelerates the reaction.
Keywords :
Hydrogen peroxide , N-Oxide isomers , alkaline , Lincomycin oxidation , Acetonitrile
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
