Title of article :
The stereoselective synthesis of novel macrolide antibacterial agents via an intramolecular 1,3-dipolar cycloaddition of azomethine ylide
Author/Authors :
Gu، نويسنده , , Yu Gui and Zhang، نويسنده , , Xiaolin and Clark، نويسنده , , Richard F. and Djuric، نويسنده , , Stevan W. and Ma، نويسنده , , Zhenkun، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
An intramolecular 1,3-dipolar cycloaddition of azomethine ylide, generated in situ via the reaction of C12-glycinate derivative of macrolide with formaldehyde, provided a novel tricyclic macrolide. The high stereoselectivity of this [2+3] reaction was achieved by introducing a suitable directing group at C-6 position of macrolide.
Keywords :
Ketolide , Azomethine ylide , macrolide
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
