Title of article :
The facile solid-phase synthesis of cholesterol-based polyamine lipids
Author/Authors :
Oliver، نويسنده , , Morag and Jorgensen، نويسنده , , Michael R. and Miller، نويسنده , , Andrew، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
A facile solid-phase methodology for the production of cholesterol-based polyamines useful in mediating nucleic acid delivery for gene therapy is described. The methodology is compatible with a range of polyamines producing a library of lipids in excellent yields (>87%) and purity.
Keywords :
nonviral gene therapy , Cationic lipids , polyamines , solid-phase synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
