Title of article :
A synthesis of camptothecin
Author/Authors :
Chavan، نويسنده , , Subhash P. and Sivappa، نويسنده , , Rasapalli Sivappa، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
A total synthesis of camptothecin has been carried out. Central to our synthesis is the intramolecular condensation of a suitably designed ketol, which in turn was obtained from a tricyclic ABC ring synthon. A tandem reductive amination and Michael addition sequence on an unsaturated quinoline ester was employed for the assembly of the ABC skeleton.
Keywords :
camptothecin , total synthesis , Tandem reductive amination–Michael addition , Ketol
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
