Title of article
Determination of the absolute stereochemistry of lupane triterpenoids by fucofuranoside method and ORD spectrum
Author/Authors
Ma، نويسنده , , Zhongze and Hano، نويسنده , , Yoshio and Qiu، نويسنده , , Feng and Chen، نويسنده , , Yingjie and Nomura، نويسنده , , Taro، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
3261
To page
3263
Abstract
The absolute configurations of the secondary alcohols at C-3 position in betulinic acid and 3-epibetulinic acid have been unambiguously determined as S- and R-configurations, respectively, based on the fucofuranoside method. The absolute stereochemistry of 3α, 27-dihydroxylupen-20(29)-en-28-oic acid methyl ester, a potent topoisomerase II inhibitor, was determined to be 3R, 5R, 8R, 9R, 10R, 13R, 14S, 17S, 18R, and 19R by NMR and ORD spectroscopic studies.
Keywords
Lupane triterpenoids , betulinic acid , Fucofuranoside method , NMR , ORD , absolute configuration
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841337
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