Title of article
Zinc-metal promoted selective α-haloacylation and gem-bisacylation of alkyl aldehydes in the presence of chlorotrimethylsilane
Author/Authors
Ishino، نويسنده , , Yoshio and Mihara، نويسنده , , Masatoshi and Takeuchi، نويسنده , , Takeshi and Takemoto، نويسنده , , Masanobu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
3503
To page
3506
Abstract
Treatment of a mixture of alkyl aldehydes (1) with acid chlorides (2) in the presence of zinc metal powder and a catalytic amount of chlorotrimethylsilane (TMSCl) in dichloromethane brought about highly facile and effective coupling to give selectively the corresponding α-haloacylation and gem-bisacylation products, α-haloalkyl carboxylates and 1,1-dicarboxylates (acylals), in good to excellent yields.
Keywords
Acylals , ?-Haloalkyl carboxylates , Zinc , TMSCl
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841427
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