Title of article
Synthetic studies of the HIV-1 protease inhibitive didemnaketals: stereocontrolled synthesis of an ester side chain
Author/Authors
Zhao، نويسنده , , Xue Zhi and Tu، نويسنده , , Yong Qiang and Peng، نويسنده , , Lei and Li، نويسنده , , Xue Qiang and Jia، نويسنده , , Yan Xing، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
3713
To page
3716
Abstract
The stereocontrolled synthesis of the C1–C8 portion, the ester side chain of the HIV-1 protease inhibitive didemnaketals from the ascidian Didemnum sp., has been carried out through 15 steps starting from (S)-carvone as the chiral template. This approach involved the diastereoselective construction of three conjoint chiral centers by intramolecular chiral inducement, and generation of allylic alcohol intermediate through a key Grob fragmentation reaction.
Keywords
Ester side chain , HIV-1 protease , Intramolecular chiral inducement , Grob fragmentation reaction
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841508
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