Title of article
4-(tert-Butyldimethylsilyloxy)benzylidene acetal: a novel benzylidene-type protecting group for 1,2-diols
Author/Authors
Kaburagi، نويسنده , , Yosuke and Osajima، نويسنده , , Hiroyuki and Shimada، نويسنده , , Kousei and Tokuyama، نويسنده , , Hidetoshi and Fukuyama، نويسنده , , Tohru، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
3817
To page
3821
Abstract
A novel 1,2-diol-protecting group, p-silyloxybenzylidene group, has been developed. In addition to the stepwise deprotection conditions including desilylation and the subsequent acidic hydrolysis of the p-hydroxybenzylidene group in AcOH–THF–H2O, we have established the one-pot deprotection under basic conditions [K2CO3 (5 equiv), NH2OH·HCl (5 equiv), and CsF (1 equiv) in MeOH–H2O].
Keywords
Diol , Deprotection under basic conditions , hydroxylamine , Protecting group , benzylidene acetal
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841559
Link To Document