1,3-Dipolar cycloaddition of exo-methylenesugars with nitrone: approach to new amino-C-ketosyl disaccharides

Stereoselective 1,3-dipolar cycloadditions of exo-methylenesugars 1a–c to a sugar nitrone 2 were carried out with refluxing a toluene solution and afforded the corresponding cycloadducts, ketosyl spiro-isoxazolidine disaccharides 3a and 4a–c. Followed by reductive cleavage of the N–O bond of the isoxazolidine ring with the treatment of Zn–AcOH–Ac2O or with catalytic hydrogenation (Pd(OH)2/C), the cycloadduct 3a could be readily converted into a novel amino-C-disaccharide possessing a ketose form, providing an access to a novel amino-C-ketosyl disaccharides.