Title of article
Microwave-assisted cleavage of Weinreb amide for carboxylate protection in the synthesis of a (R)-3-hydroxyalkanoic acid
Author/Authors
Kwang-Seuk and Jaipuri، نويسنده , , Firoz A. and Francisca Jofre، نويسنده , , M. and Schwarz، نويسنده , , Kimberly A. and Pohl، نويسنده , , Nicola L.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
4149
To page
4152
Abstract
A versatile route for the modular synthesis of (R)-3-hydroxyalkanoic acids, constituents of the naturally biodegradable poly(3-hydroxyalkanoate) polymers, and its application to the synthesis of (R)-3-hydroxydecanoic acid is described. Key steps include a microwave-assisted catalytic transfer hydrogenation and a facile microwave-assisted hydrolysis of an N-methoxy-N-methyl (Weinreb) amide, which enhances the practicality of this protecting group for carboxylic acids.
Keywords
Microwaves , Weinreb amide , Chirality , chiral building blocks , Wittig reaction , (R)-3-Hydroxyalkanoic acids
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841704
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