Application of polydentate chiral amines within magnesium-mediated asymmetric deprotonation reactions

A set of polydentate secondary amines, each containing two stereogenic centres, were prepared. These were subsequently utilised in magnesium-mediated asymmetric deprotonation reactions and excellent enantiomeric ratios were obtained (up to 94:6 er). Furthermore, these bases tend to be highly efficient in the absence of strong Lewis base additives, which demonstrates an additional practical advantage over existing protocols.