Title of article
Stereoselective nitrenium ion cyclizations: asymmetric synthesis of the (+)-Kishi lactam and an intermediate for the preparation of fasicularin
Author/Authors
Wardrop، نويسنده , , Duncan J. and Zhang، نويسنده , , Wenming and Landrie، نويسنده , , Chad L.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
4229
To page
4231
Abstract
The asymmetric synthesis of the (+)-Kishi lactam and an intermediate for the preparation of the marine natural product fasicularin is reported. The keystone of this divergent synthesis is the diastereoselective azaspirocyclization of an N-methoxy γ-arylbutanoamide, which is believed to proceed through the intermediacy of an N-acylnitrenium ion.
Keywords
Histrionicotoxin , Dearomatization , Nitrenium ions , Polyvalent iodine , Fasicularin
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1841737
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