Title of article :
Incorporation of the bioactive moiety of leinamycin into thymidine
Author/Authors :
Szilلgyi، نويسنده , , ءkos and Pelyvلs، نويسنده , , Istvلn F. and Majercsik، نويسنده , , Orsolya and Herczegh، نويسنده , , Pلl، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
A simple synthesis of 1,2-dithiolan-3-ones from α,β-unsaturated thiophenyl esters has been elaborated. With the aim of introducing the biologically active 1,2-dithiolan-3-one-1-oxide moiety of leinamycin into a nucleoside, the method was successfully applied to thymidine-5′-aldehyde.
Keywords :
DNA cleaving , Wittig reaction , conjugate addition , ring closure , Leinamycin
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
