Title of article :
Efficient access to chiral β-arylamides via asymmetric 1,4-additions of potassium trifluoro(organo)borates
Author/Authors :
Pucheault، نويسنده , , Mathieu and Michaut، نويسنده , , Valérie and Darses، نويسنده , , Sylvain and Genet، نويسنده , , Jean-Pierre، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
This paper describes an efficient enantioselective conjugate addition of highly stable potassium trifluoro(organo)borates to α,β-unsaturated amides. This reaction, catalyzed by chiral rhodium(I) complexes affords Michael adducts with high yields and enantiomeric excesses up to 95%.
Keywords :
Enamides , Asymmetric catalysis , borates , 4-addition , Rhodium , 1
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
