Title of article
Synthesis and characterization of a bunchy oligonucleotide forming a monomolecular parallel quadruplex structure in solution
Author/Authors
Oliviero، نويسنده , , Giorgia and Borbone، نويسنده , , Nicola and Galeone، نويسنده , , Aldo and Varra، نويسنده , , Michela and Piccialli، نويسنده , , Gennaro and Mayol، نويسنده , , Luciano، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
4869
To page
4872
Abstract
A cluster of four d(TG4T) hexanucleotides with the 3′-ends linked together by a bunchy spacer has been synthesized and shown to form a monomolecular parallel quadruplex 5 in solution characterized by four G-quartets. 1H NMR spectroscopy and CD thermal denaturation experiments indicate the monomolecular quadruplex (5) to be more stable than the tetramolecular counterpart [d(TG4T)]4.
Keywords
G-quartets , solid-phase synthesis , quadruplex , DNA
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842132
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