Title of article :
Vinylogous Mannich reactions. Additions of trimethylsilyloxyfuran to fluorinated aldimines
Author/Authors :
Spanedda، نويسنده , , Maria Vittoria and Ourévitch، نويسنده , , Michèle and Crousse، نويسنده , , Benoit and Bégué، نويسنده , , Jean-Pierre and Bonnet-Delpon، نويسنده , , Danièle، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
Trifluoromethyl aldimines reacted with trimethylsilyloxyfuran in presence of Lewis acids to provide butenolides in high yields with total diastereoselectivity (>98%). The configuration of these products is anti. The butyrolactone 4a, substituted with a 2-trifluoromethyl ethyl amine, could be converted into a trans α-trifluoromethyl piperidine derivative.
Keywords :
Vinylogous Mannich reaction , Trifluoromethyl aldimines , Trifluoromethyl butenolides , Trifluoromethyl piperidines
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
