Title of article :
Nitrobenzylation of α-carbonyl ester derivatives using TDAE approach
Author/Authors :
Giuglio-Tonolo، نويسنده , , Gamal and Terme، نويسنده , , Thierry and Médebielle، نويسنده , , Maurice and Vanelle، نويسنده , , Patrice، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
A series of 2-hydroxy-propionic acid ethyl ester derivatives was prepared in good yields by reaction of o- and p-nitrobenzyl chlorides (1, 8) with various α-carbonyl esters in presence of tetrakis(dimethylamino)ethylene (TDAE). This reaction was generalized to α-ketolactam and α-ketomalonate.
Keywords :
p-nitrobenzyl chloride , ?-Carbonyl ester , ?-Hydroxy ester , TDAE
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
