Title of article
A lactam-derived vinyl boronate as a stable and crystalline reagent for the synthesis of 2-substituted piperidines by Pd-catalyzed coupling reactions
Author/Authors
Ferrali، نويسنده , , Alessandro and Guarna، نويسنده , , Antonio and Lo Galbo، نويسنده , , Fabrizio and Occhiato، نويسنده , , Ernesto G.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
5271
To page
5274
Abstract
A δ-valerolactam-derived vinyl triflate has been converted into the corresponding vinyl boronate by Pd-catalyzed coupling with bis(pinacolato)diboron, which results in an umpolung. This boronate efficiently couples under Pd catalysis with aryl and heteroaryl bromides to give the corresponding 2-substituted piperidines in excellent yields.
Keywords
lactams , Boronates , Triflates , PALLADIUM , Coupling , piperidines
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842314
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