Author/Authors :
Idbaih، نويسنده , , A. and Taillibert، نويسنده , , S. and Simon، نويسنده , , Psimaras، نويسنده , , D. and Schneble، نويسنده , , H.-M. and Lopez، نويسنده , , S. and Lang، نويسنده , , P. and Toubiana، نويسنده , , T. and Feuvret، نويسنده , , L. and Delattre، نويسنده , , J.-Y. and Mazeron، نويسنده , , J.-J.، نويسنده ,
Abstract :
Purpose
timal schedule of irradiation in elderly patients suffering from glioblastoma multiforme (GBM) is unsettled.
als and methods
tudy reviewed the charts of 28 consecutive GBM patients aged 70 years or more with a Karnofsky Performance Status (KPS) greater than or equal to 70 who received a short course of radiotherapy (40 grays in 15 fractions over three weeks).
s
dian age at surgery was 74.6 years (range, 70.1–85.7). No patient received prior or concomitant chemotherapy. The median progression-free survival and overall survival were 21.6 weeks (95% CI, 17.0–39.9) and 50.6 weeks (95% CI, 26.3–62.0), respectively. Even within a narrow range (< 90 or ≥ 90), KPS remained a prognostic factor (p = 0.03). Tolerance appeared acceptable in terms of KPS changes and corticosteroid use during radiation therapy.
sion
results support the efficacy of short schedule radiotherapy for GBM in elderly patients with a good KPS.
Keywords :
Accélérée , Elderly , Glioblastoma multiforme , Glioma , Karnofsky performance status , radiotherapy , آgé , Glioblastome multiforme , Gliome , Indice de performance Karnofsky , Radiothérapie , Hypofractionnée
