Title of article :
The first total synthesis of SB87-Cl and pestalone, novel bioactive benzophenone natural products
Author/Authors :
Iijima، نويسنده , , Daisuke and Tanaka، نويسنده , , Daisuke and Hamada، نويسنده , , Motoko and Ogamino، نويسنده , , Takahisa and Ishikawa، نويسنده , , Yuichi and Nishiyama، نويسنده , , Shigeru، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
SB87-Cl 1, an inhibitor of testosterone-5α-reductase, and pestalone 2 exhibiting effective antimicrobial activity against MRSA (MIC = 37 ng/mL) and VRE (MIC = 78 ng/mL), were novel bioactive benzophenone natural products. Total synthesis of 1 and 2 has been successfully accomplished. The common synthetic precursor 18 of 1 and 2, was successfully obtained by the coupling of 8 with 12.
Keywords :
Pestalone , MRSA , VRE , Chrysosporium , SB87-Cl , Testosterone-5?-reductase , Pestalotia
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
