Title of article :
A new insight into the Pfitzinger reaction. A facile synthesis of 6-sulfamoylquinoline-4-carboxylic acids
Author/Authors :
Ivachtchenko، نويسنده , , Alexandre V and Khvat، نويسنده , , Alexander V and Kobak، نويسنده , , Vladimir V and Kysil، نويسنده , , Volodymir M and Williams، نويسنده , , Caroline T، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
The unusual formation of 6-sulfamoylquinoline-4-carboxylic acids from 5-sulfamoylisatins under the conditions of Pfitzinger reaction is described. Key step in the suggested mechanism is the reaction of in situ generated acetaldehyde with the hydrolytically cleaved isatin ring. The suggested mechanism has been confirmed by dynamic LCMS measurements and by reactions with isotopically labeled reactants.
Keywords :
Pfitzinger reaction , 5-Sulfamoylisatins , Quinoline-4-carboxylic acids , Acetaldehyde , Ethanol
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
