Author/Authors :
Sato، نويسنده , , Kazuyuki and Tarui، نويسنده , , Atsushi and Kita، نويسنده , , Tetsuya and Ishida، نويسنده , , Yoshitaka and Tamura، نويسنده , , Hanae and Omote، نويسنده , , Masaaki and Ando، نويسنده , , Akira and Kumadaki، نويسنده , , Itsumaro، نويسنده ,
Abstract :
Treatment of a variety of carbonyl compounds with ethyl bromodifluoroacetate and Et2Zn in the presence of RhCl(PPh3)3 in CH3CN afforded Reformatsky-type products in good to excellent yields in a mild reaction condition. This is a good method to obtain a β-hydroxy-α,α-difluoro carboxylic acid ethyl ester and especially to improve the poor reactivity of ketones.
Keywords :
Reformatsky reaction , Rhodium , fluorine , Difluoroacetate
