Author/Authors :
Sakaguchi، نويسنده , , Kazuhiko and Yamamoto، نويسنده , , Masahiro and Kawamoto، نويسنده , , Tetsuo and Yamada، نويسنده , , Takeshi and Shinada، نويسنده , , Tetsuro and Shimamoto، نويسنده , , Keiko and Ohfune، نويسنده , , Yasufumi، نويسنده ,
Abstract :
The synthesis of four types of optically active β-carbon-substituted analogs of threo-β-hydroxy aspartate (THA) and a β-carbon-substituted analog of threo-β-benzyloxy aspartate (TBOA), which are potent blockers of excitatory amino acid transporters in the mammalian central nervous system, via the chirality-transferring ester–enolate Claisen rearrangement of α-acyloxytrialkylsilane is described.
Keywords :
threo-?-Hydroxy aspartate , Glutamate transporter , ?-Acyloxysilane , threo-?-Benzyloxy aspartate , Ester–enolate Claisen rearrangement , ?-hydroxysilane
