Title of article :
Design and synthesis of a novel water-soluble Aβ1-42 isopeptide: an efficient strategy for the preparation of Alzheimerʹs disease-related peptide, Aβ1-42, via O–N intramolecular acyl migration reaction
Author/Authors :
Sohma، نويسنده , , Youhei and Sasaki، نويسنده , , Masato and Hayashi، نويسنده , , Yoshio and Kimura، نويسنده , , Tooru and Kiso، نويسنده , , Yoshiaki، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
A novel water-soluble isopeptide of Alzheimerʹs disease-related peptide Aβ1-42, `26-O-acyl isoAβ1-42ʹ, which could efficiently convert to intact Aβ1-42 under physiological conditions via O–N intramolecular acyl migration, was synthesized providing a new system useful for investigation of biological function of Aβ1-42.
Keywords :
Water-soluble A?1-42 isopeptide , A?1-42 , Alzheimerיs disease , O–N intramolecular acyl migration reaction , Difficult sequence , 26-O-acyl isoA?1-42
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
