Author/Authors :
Ha، نويسنده , , Jae Du and Kim، نويسنده , , Sun Young and Lee، نويسنده , , Su Jung and Kang، نويسنده , , Seung Kyu and Ahn، نويسنده , , Jin Hee and Kim، نويسنده , , Sung Soo and Choi، نويسنده , , Joong-Kwon، نويسنده ,
Abstract :
The regio- and stereoselective ring opening of vinyl epoxides has been achieved by the use of Lewis acid, MgBr2, affording bromohydrins in excellent yield, which are readily transformed to azidoalcohol, a key intermediate of several classes of pyrrolizidine and indolizidine alkaloids. The scope and limitations of the reaction are discussed.
Keywords :
vinyl epoxide , Ring opening , bromohydrin , MgBr2
