Synthesis of deuterium labeled compounds by KCN-assisted hydrolysis of phosphonium salts
Author/Authors :
Lee، نويسنده , , Ka Young and Na، نويسنده , , Jeong Eun and Lee، نويسنده , , Mi Jung and Kim، نويسنده , , Jae Nyoung، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Pages :
5
From page :
5977
To page :
5981
Abstract :
We developed a facile deuterium labeling method for benzylic or allylic halides or acetates systems. Conversion of the halides or acetates to the corresponding phosphonium salts and the following mild hydrolysis with KCN afforded the deuterium labeled compounds in good yields.
