Title of article
Highly selective synthesis of 2-substituted-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid derivatives using a novel protected dihydroxyfumarate
Author/Authors
Dreher، نويسنده , , Spencer D. and Ikemoto، نويسنده , , Norihiro and Gresham، نويسنده , , Venita and Liu، نويسنده , , Jinchu and Dormer، نويسنده , , Peter G. and Balsells، نويسنده , , Jaume and Mathre، نويسنده , , David C. Novak، نويسنده , , Thomas J. and Armstrong III، نويسنده , , Joseph D.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
6023
To page
6025
Abstract
A high yielding (50–96%) route to 2-substituted-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid derivatives has been developed using a rationally designed dihydroxyfumarate derivative. The fully unprotected pyrimidinone heterocycle was prepared in quantitative yield upon treatment with HCl.
Keywords
Pyrimidine , Fumarate , Pyrimidinone
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1842849
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