Title of article :
Oxazolidine-2-thiones: a molecular modeling study
Author/Authors :
Gandhi، نويسنده , , Neha and Srivastava، نويسنده , , Brijesh K. and Lohray، نويسنده , , Vidya B. and Lohray، نويسنده , , Braj B. Lohray، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding.
Keywords :
Thioacetamide , Linezolid , oxazolidine-2-thiones , molecular modeling , 23S Rrna , Antibacterial , Piecewise linear potential (PLP)
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
