Author/Authors :
Lubov Pasumansky، نويسنده , , Lubov and Hernلndez، نويسنده , , Armando R. and Gamsey، نويسنده , , Soya and Goralski، نويسنده , , Christian T. and Singaram، نويسنده , , Bakthan، نويسنده ,
Abstract :
Lithium amides promote the amination of 2-fluoropyridine under mild reaction conditions, providing 2-aminopyridines in good yields and purity. Treatment of 2-fluoropyridine with 1 equiv of lithium amide at room temperature affords complete conversion after 2 h. To our knowledge, this is the first study of lithium amide-promoted amination of fluoropyridines that are not further activated by electron-withdrawing groups.
