Author/Authors :
Li، نويسنده , , Bryan and Buzon، نويسنده , , Richard A. and Chiu، نويسنده , , Charles K.-F. and Colgan، نويسنده , , Stephen T. and Jorgensen، نويسنده , , Matthew L. and Kasthurikrishnan، نويسنده , , Narasim، نويسنده ,
Abstract :
A short, efficient, and highly diastereoselective synthesis of 5-[(1S)-N-Boc-amino-(2S)-(3-fluorophenyl)ethyl]-dihydrofuran-2-one (1) is described. Use of phthalic anhydride as thiolate scavenger effectively preserves the chiral integrity of the α-aminoketone 4 product obtained from the reaction of organozincate 3 with thioester 2.
